Mapping along-tract commissural and association white matter microstructural differences in autistic children and young adults.

ABSTRACT: Previous diffusion magnetic resonance imaging (dMRI) research has indicated altered white matter microstructure in autism, but the implicated regions are inconsistent across studies. Such prior work has largely used conventional dMRI analysis methods, including the traditional microstructure model, diffusion tensor imaging (DTI). However, these methods are limited in their ability to precisely map microstructural differences and accurately resolve complex fiber configurations. In our study, we investigated white matter microstructure alterations in autism using the refined along-tract analytic approach, BUndle ANalytics (BUAN), with both an advanced microstructure model, the tensor distribution function (TDF) and DTI. We analyzed dMRI data from 365 autistic and neurotypical participants (5

SUBMITTER: Kim GS 

PROVIDER: S-EPMC12613831 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature