Dose-dependent effects of cannabidiol in drinking water on yolk fatty acid profile and hepatic expression of polyunsaturated fatty acids (PUFAs) -related genes in laying hens: insights into the cannabidiol (CBD) systemic and molecular mechanisms of action.

ABSTRACT: The present research evaluated the effect of water-soluble cannabidiol (CBD) emulsion on egg yolk fatty acid profile, liver health, and gene expression in laying hens. 180 Lohmann Brown Classic hens were divided into experimental groups, including a control group, a blank group (emulsifier only), and three groups receiving CBD. Cannabidiol was administered in drinking water for 15 weeks at doses of 20, 40, and 80 mg/kg body weight in group I, group II, and group III, respectively. The analysis indicated that the highest-dose CBD significantly increased yolk polyunsaturated fatty acids (PUFAs), particularly omega-3 and omega-6, as well as the serum HDL level. However, this was accompanied by downregulation of PPAR-γ expression. The histopathology of the liver did not show any differences am

SUBMITTER: Fallahi S 

PROVIDER: S-EPMC12613878 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature