Association of fructose-1,6-diphosphatase 1 with the progression of diabetic kidney disease.

ABSTRACT:

Background

Diabetic Kidney Disease (DKD) is one of the most serious complications of diabetes mellitus, and a main cause of end-stage kidney disease (ESKD). The identification of clinically applicable molecular biomarkers for monitoring DKD progression has become increasingly essential. In this study, we aim to investigate the relationship between the expression of fructose-1,6-bisphosphatase 1 (FBP1), a rate-limiting enzyme in gluconeogenesis, and DKD.

Methods

A two-sample Mendelian randomization (MR) analysis was conducted using plasma protein quantitative trait loci data obtained from deCODE genetics and DKD genome-wide association study data acquired from the Finnish Biobank Alliance to assess the causal relationship between FBP1 and DKD. In parallel, a retrospective coh

SUBMITTER: Fu Z 

PROVIDER: S-EPMC12613888 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature