Longitudinal dysbiosis of gut bacteriome and mycobiome in patients with severe acute pancreatitis and its association with mortality.

ABSTRACT:

Background

The dysbiosis of gut microbiome is known to have a significant impact on the progression of sever acute pancreatitis (SAP). This study intends to investigate the alteration of gut microbiome in SAP patients during hospitalization and its association with mortality. Bacterial and fungal compositions of the fecal microbiota were determined via 16S and ITS1 sequencing, respectively.

Results

Our findings indicated that SAP patients exhibited bacterial and fungal dysbiosis either at the time of admission or within the first 72 h of admission prior to any antibiotic treatment, characterized by reduced biodiversity, lower abundances of Blautia, Bifidobacterium, and increased Escherichia-Shigella, Enterococcus, and Candida. The overall microbiome was partially restored po

SUBMITTER: He C 

PROVIDER: S-EPMC12613924 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature