Association of Choroid Plexus Dysfunction and Cognitive Decline in Preeclampsia: Using T1WI Imaging, Quantitative Susceptibility Mapping and Deep-Learning-Based Segmentation.

ABSTRACT: Preeclampsia is a severe pregnancy complication that can cause brain injury, yet early detection of related cognitive deficits remains challenging. Therefore, in order to investigate alterations in choroid plexus volume (CPV) and susceptibility values of the choroid plexus (ChP) obtained from quantitative susceptibility mapping (QSM) in preeclampsia patients, we enrolled 281 participants, comprising 98 nonpregnant healthy controls (NPHC), 85 pregnant healthy controls (PHC), and 98 patients with preeclampsia. All participants were scanned on a 1.5 T MR scanner. The results of clinical characteristics and cognitive tests were collected from all the participants. One-way ANOVA tests were used to analyze the differences in CPV and susceptibility values of ChP among the three groups. Multiple l

SUBMITTER: Chen B 

PROVIDER: S-EPMC12614088 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature