Assessment of distinct effects of <i>Parinari curatellifolia</i> Planch.ex Benth Ethanolic leaf extract on glucose transport in different cell types.

ABSTRACT: Extracts of Parinari curatellifolia Planch.ex Benth have been used as a traditional medicine in Sub-Saharan Africa for the management of various ailments including diabetes and has been shown to reduce plasma glucose levels in rat models of diabetes. Treatment of a range of mammalian cell lines with P. curatellifolia ethanolic leaf extract (PCE) for 24-48 h, typically between 0 and 100 µg/mL, revealed different actions: in 3T3-L1 adipocytes, PCE markedly inhibited insulin-stimulated glucose transport (50% inhibition at 100 µg/mL), whereas by contrast PCE-treatment of Caco-2 cells, a model of the intestinal epithelia at the same concentration, increased glucose transport ∼2-fold. This effect was accompanied by increased glucose transporter-1 (GLUT1) levels but is independent o

SUBMITTER: Omale S 

PROVIDER: S-EPMC12614100 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature