Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals.

ABSTRACT:

Background

High birth weight is associated with adult body mass index (BMI). We hypothesized that birth weight and BMI may partly share a common genetic background.

Objective

The objective was to examine the associations of 12 established BMI variants in or near the NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, BCDIN3D, SH2B1, FTO, MC4R, and KCTD15 genes and their additive score with birth weight.

Design

A meta-analysis was conducted with the use of 1) the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk, Hertfordshire, Fenland, and European Youth Heart Study cohorts (n(max) = 14,060); 2) data extracted from the Early Growth Genetics Consortium meta-analysis of 6 genome-wide association studies for birth weight (n(max) = 10,623); and 3)

SUBMITTER: Kilpelainen TO 

PROVIDER: S-EPMC12614105 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature