Neuroanatomical profile of BMI implicates impulsive delay discounting and general cognitive ability.

ABSTRACT:

Objective

Obesity is a disorder of excessive adiposity, typically assessed via the anthropometric density measure of BMI. Numerous studies have implicated BMI with differences in brain structure, but with highly inconsistent findings.

Methods

Machine learning elastic net regression models with cross-validation were conducted to characterize a neuroanatomical morphometry profile associated with BMI in 1100 participants (22% BMI > 30, n = 242) from the Human Connectome Project Young Adult project.

Results

Using five-fold cross-validation, the multiregion neuroanatomical profile substantively predicted BMI (R²  = 10.05%), and this was robust in a held-out test set (R²  = 8.87%). In terms of specific regions, the neuroanatomical profile was enriched

SUBMITTER: Xu H 

PROVIDER: S-EPMC12614112 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature