Base-mediated three-component system for the synthesis of <i>S</i>-substituted <i>N</i>-acyl ureas.

ABSTRACT: N-Acyl ureas are crucial intermediates in the synthesis of biologically active molecules, and their preparation traditionally relies on multi-step synthesis under reflux conditions. Here, we report a three-component system that combines widespread alkyl halides, thiourea and carbamoyl chlorides. Crucial to this strategy is the synthesis of specific S-substituted N-acyl ureas via the formation of the isothiouronium salt intermediates. This developed three-component system affords scalable and functional group-tolerant reactivity, furnishing the desired products in good to excellent yields under mild conditions.

SUBMITTER: Shandu MP 

PROVIDER: S-EPMC12614162 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature