Impact of absent in melanoma 2 on head and neck squamous cell carcinoma development.

ABSTRACT: Head and neck squamous cell carcinoma (HNSCC) constitutes 90% of head and neck cancers. HNSCC development is linked to chronic inflammation, while established HNSCC tumors are often immune suppressive. However, both occur through mechanisms that are not fully understood. The cytosolic double-stranded DNA sensor absent in melanoma 2 (AIM2) is an inflammasome-forming protein that also has inflammasome-distinct roles in restricting tumorigenesis by limited PI3K signaling. Here, we used an experimental mouse model of HNSCC, involving treatment of wild-type (WT) and Aim2-/- mice with the carcinogen 4NQO in drinking water. Compared with WT mice, 4NQO-treated Aim2-/- mice exhibited larger tumors and increased tissue dysplasia. 4NQO-treated WT and Aim2-/- mice displayed similar tongue Il6, Tnf, Il

SUBMITTER: Reinartz DM 

PROVIDER: S-EPMC12614266 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature