Performance Evaluation of Constant Field and Traveling Wave-Based Structures for Lossless Ion Manipulations Devices Coupled to Mass Spectrometry.

ABSTRACT: The performances of three prototype structures for lossless ion manipulations IMS mass spectrometer (SLIM IMS-MS) are evaluated. The instrument was constructed by replacing the drift tube of an Agilent 6560 with either traveling wave (TW) or constant field (CF) based SLIM modules of nearly identical length. The TW-SLIM module contains a 79.4 cm straight path and a 10 m serpentine path. The evaluation of these systems enabled the direct determination of performance differences associated with the drift tube replacement by the SLIM devices. The evaluation included comparing the resolution, resolving power, transmitted mass range, and collisional cross-section (CCS) accuracy relative to its drift tube counterpart for each device/path. Results indicated that the 79.4 cm CF-SLIM displayed compa

SUBMITTER: Harrilal CP 

PROVIDER: S-EPMC12614303 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature