<i>Trypanosoma cruzi</i> infection-induced changes in cardiac microvascular endothelial cell morphology and function.

ABSTRACT: Introduction. Six to seven million individuals are infected with Trypanosoma cruzi, the causative agent of Chagas disease. With 12,000 deaths annually, chronic Chagas disease remains a significant global health challenge due to persistent vector transmission, increasing non-vector transmission and limited therapeutic options. Chronic Chagas cardiomyopathy is a leading cause of morbidity and mortality, yet the underlying mechanisms remain poorly understood.Gap Statement. Since its initial description more than 100 years ago, research efforts into the cardiomyopathy found in chronic Chagas disease have primarily focused on the contributions of immune cells, cardiomyocytes and cardiac fibroblasts, leaving a significant gap in understanding the role of microvascular endoth

SUBMITTER: Gisclair LN 

PROVIDER: S-EPMC12614368 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature