Measurement of microdosimetric spectra of high-LET particle beams using the ENCORE detector.

ABSTRACT:

Background

Heavy ion radiotherapy offers distinct advantages over conventional treatments due to its superior dose distribution and enhanced biological effectiveness. However, the microdosimetric characteristics of high linear energy transfer (LET) ions, particularly near the Bragg peak, remain poorly characterized. Most experimental microdosimetry has been conducted at lower LETs, leaving a critical gap in high-LET microdosimetric data.

Purpose

This study aims to extend microdosimetry to several different high-LET ions (700-2500 keV/µm) using the novel ENCORE detector.

Methods

Microdosimetry was performed at the Florida State University John D. Fox Accelerator Laboratory using the ENCORE detector, a multi-sampling ionization chamber filled with low-pressure tissue-eq

SUBMITTER: Hartzell S 

PROVIDER: S-EPMC12614413 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature