Age-Dependent Role of Genetics and Renal Function for Atrial Fibrillation Development in Hypertrophic Cardiomyopathy.

ABSTRACT:

Background and objectives

The objective of this study was to investigate whether genetic, structural, and clinical factors were associated with atrial fibrillation (AF) in patients with hypertrophic cardiomyopathy (HCM).

Methods

Of the 212 prospectively enrolled patients in the HCM genetic registry, 33 had initial AF, and the remaining 179 (126 males, 58±13 years) were followed up for the development of new-onset AF.

Results

Patients with initial AF had older age, lower estimated glomerular filtration rate (eGFR), lower left ventricular (LV) global longitudinal strain, higher left atrial volume index (LAVI), and higher LV extracellular volume fraction. During a median follow-up period of 916 (400-1,327) days, AF occurred in 12 (6.7%) patients. In Cox regression analys

SUBMITTER: Chung H 

PROVIDER: S-EPMC12614428 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature