NGF/ERK signaling-mediated epigenetic regulation of neuropathic pain in the cerebrospinal fluid-contacting nucleus.

ABSTRACT:

Objective

Neuropathic pain (NP) is a debilitating condition that is associated with multiple molecular alterations in the nervous system. This is the first study to demonstrate the epigenetic regulatory function of nerve growth factor (NGF), mediated through the extracellular signal-regulated kinase (ERK) signaling pathway in the cerebrospinal fluid-contacting nucleus (CSF-CN), in relation to NP. The objective of this study was to characterize the role of NGF in this specific brain region and its downstream effects on histone acetylation in the chronic constriction injury (CCI) rat model.

Methods

A rat model of NP was established using CCI. The study investigated the expression of NGF and its impact on pain pathways. NGF levels in the CSF-CN were assessed, and the effects of

SUBMITTER: Li G 

PROVIDER: S-EPMC12614463 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature