Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke.

ABSTRACT:

Background

The combination of task-oriented training and vagus nerve stimulation has recently received US Food and Drug Administration approval to improve upper limb recovery in individuals with chronic stroke. Although conventional vagus nerve stimulation systems have a long track record of solid performance, they have been minimally redesigned since their entry onto the market in 1997 and are ripe for improvement. To leverage this opportunity, we developed a miniaturized system tailored specifically for closed-loop vagus nerve stimulation therapy (CLV). The system is ≈50-fold smaller, simplifies implantation, and interacts with sensors for closed-loop triggering during personalized rehabilitation sessions. Here, we performed a randomized, sham-controlled trial to evaluate the saf

SUBMITTER: Hays SA 

PROVIDER: S-EPMC12614473 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature