Comparison of treatment outcomes of direct oral anticoagulants and heparin for patients with Takotsubo cardiomyopathy: A nationwide cohort analysis.

ABSTRACT: Takotsubo cardiomyopathy is characterized by temporary ballooning of the left ventricle and may lead to thrombosis, necessitating anticoagulation therapy in high-risk patients. However, no previous studies have compared anticoagulation therapies for this population. We aimed to compare the clinical outcomes of patients treated with direct oral anticoagulants (DOACs) and those treated with heparin. This retrospective study included patients with Takotsubo cardiomyopathy receiving DOACs or heparin within the first 2 days of admission between April 2012 and March 2021, identified from a nationwide in-hospital database in Japan. The primary outcome was in-hospital mortality. The secondary outcomes were ischemic and bleeding events, hospitalization costs, and length of hospital stay. After adju

SUBMITTER: Hijikata S 

PROVIDER: S-EPMC12614514 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature