Establishing an Elastography calibration standard: Validation of a shear wave TOF device for measuring Elasticity and Viscosity in tissue-mimicking phantoms using rheometry.

ABSTRACT: This study designed a novel shear wave Time of Flight (TOF) device to measure frequency-dependent shear wave velocity in tissue-mimicking materials, from which viscoelastic parameters were estimated through Kelvin-Voigt fractional derivative modeling to establish a reliable calibration standard. Tissue-mimicking phantoms were fabricated using 10 wt% polyvinyl alcohol (PVA) and 2 wt% α-alumina powder, with mechanical properties modulated through freeze-thaw cycling. Bimorph transducers operating in the 40-180 Hz range induced and captured shear waves. A single-cycle sine wave excitation ensures narrowband propagation, and a custom algorithm based on the cumulative energy technique robustly detects the shear wave arrival time to estimate TOF. Frequency-dependent shear velocity data were fitt

SUBMITTER: Kimondo JJ 

PROVIDER: S-EPMC12614516 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature