Large-Scale Proteomics Reveals New Candidate Biomarkers for Late-Onset Preeclampsia.

ABSTRACT:

Background

Preeclampsia is classified as either a more severe early onset or a more prevalent late-onset form. Lower PlGF (placental growth factor) and increased sFlt-1 (fms-like tyrosine kinase-1) in maternal circulation are promising biomarkers, yet they lack specificity for preeclampsia.

Methods

We quantified ≈7000 proteins in 673 samples collected from 89 patients with late-onset preeclampsia and 91 controls at T1 (15-22), T2 (22-30), and T3 (30-42) weeks. Elastic net and random forest models were fitted and evaluated by cross-validation. Differential abundance analysis followed by functional profiling, was used to identify and interpret protein changes.

Results

An increase in protein differential abundance in late-onset preeclampsia was observed with advancing ge

SUBMITTER: Andresen IJ 

PROVIDER: S-EPMC12614630 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature