Ferroptosis-associated RNA-binding proteins predict clinical outcomes in head and neck squamous cell carcinoma.

ABSTRACT:

Background

Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy with limited improvements in survival outcomes. Increasing evidence highlights the role of ferroptosis, an iron-dependent form of regulated cell death, and RNA-binding proteins (RBPs) in tumor progression. However, the prognostic significance of ferroptosis-associated RBPs in HNSCC remains unclear. This study aimed to develop and validate a ferroptosis-associated RBP signature to improve survival prediction and explore its relationship with the immune microenvironment in HNSCC.

Methods

A prognostic RBP signature was developed through systematic bioinformatics screening of ferroptosis-associated genes in HNSCC cohorts. Utilizing multi-omics data from The Cancer Genome Atlas (TCGA) and Gene Ex

SUBMITTER: Liu M 

PROVIDER: S-EPMC12614652 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature