KRT23 promotes proliferation invasion and metastasis of gastric cancer through epithelial-mesenchymal transition mediated by the PI3K/AKT/mTOR signaling pathway.

ABSTRACT:

Background

Gastric cancer (GC) is a highly prevalent and lethal malignancy worldwide. Notwithstanding advances in treatment, suboptimal patient outcomes highlight the urgent need for novel therapeutic targets to improve survival. This study aimed to explore the influence of keratin 23 (KRT23) on the proliferation, migration, and invasion of GC cells, as well as its underlying molecular mechanism.

Methods

In this research, the correlation between KRT23 expression and prognosis in GC and the sensitivity analysis of chemotherapy drugs were predicted using bioinformatics methods. The expression pattern of KRT23 in GC samples and cells was examined through immunohistochemistry, quantitative polymerase chain reaction (qPCR), and Western blot. Treatments involving KRT23 knockdown i

SUBMITTER: Xie Y 

PROVIDER: S-EPMC12614655 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature