Interleukin-18 binding protein protects against metabolic steatohepatitis.

ABSTRACT:

Background

Metabolic dysfunction-associated steatohepatitis (MASH) is a frequent consequence of Western diet consumption and liver steatosis. IL-18 binding protein (IL-18BP) limits the action of interleukin-18 (IL-18). Our work aims to study the unknown role of IL-18BP in MASH progression.

Methods

We analyzed the liver transcriptome from MASH patients. We investigated cell-specific expressions of IL-18, IL-18BP, and IL-18 receptor in human and mouse liver. We studied the liver phenotype of Il18bp-/- mice on a high-fat/high-cholesterol (HFHC) diet. We administered an anti-IL-18 antibody in Il18bp-/- mice and in diet-induced wild-type (WT) MASH mice. We generated and studied double knock-out Il18bp-/-Ifng-/- mice.

Results

IL-18BP expression is increased in the liver of

SUBMITTER: Somm E 

PROVIDER: S-EPMC12614690 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature