The β_IV-Spectrin/STAT3 Complex Regulates the Orientation of Cardiac Hypertrophic Growth.

ABSTRACT:

Background

Cardiac hypertrophy, defined as a stress-induced increase in heart mass/size, is a major risk factor for adverse cardiovascular events, including heart failure and arrhythmia. Within this general definition, the orientation of cell and organ growth varies considerably depending on stress type and duration, with important implications for cardiac function, yet little is known regarding the mechanisms that regulate hypertrophic orientation. Here, we evaluated the role of the cytoskeletal protein β_IV-spectrin and associated prohypertrophic STAT3 (signal transducer and activator of transcription 3) to direct the orientation of hypertrophic growth.

Methods

Transgenic mouse models with altered STAT3 signaling through modified interaction with its scaffolding

SUBMITTER: Nassal DM 

PROVIDER: S-EPMC12614771 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature