The VelB IDD promotes selective heterodimer formation of velvet proteins for fungal development.

ABSTRACT: Fungi possess several transcription factors with a characteristic velvet domain for DNA binding and homo- or heterodimerization, which is structurally similar to the mammalian NF-κB Rel homology domain. Velvet dimers control fungal development, virulence, and mycotoxin formation. VelB is the only regulator, which carries an intrinsically disordered domain (IDD) within the velvet domain. The IDD, as well as the positioning within VelB, is conserved in the fungal kingdom. Intrinsically disordered regions contribute to transcription activation and DNA binding and frequently appear in eukaryotic transcription factors. The VelB IDD provides selective heterodimerization and protein stability control. The IDD is not required for the formation of the VelB-VeA heterodimer of Aspergillus nidulans

SUBMITTER: Kohler AM 

PROVIDER: S-EPMC12614781 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature