Targeting interictal low-entropy zones during epilepsy surgery predicts successful outcomes in pediatric drug-resistant epilepsy.

ABSTRACT:

Objective

Approximately 40% of children undergoing epilepsy surgery have postoperative seizures, underscoring the need for enhanced estimators of the epileptogenic zone (EZ). We hypothesize that visually imperceptible low-entropy activity in the interictal periods, even in the absence of conventional spikes, is a robust signature of the EZ. To test this, we mapped interictal "low-entropy zones" using intracranial electroencephalography (iEEG) in children with drug-resistant epilepsy (DRE) and assessed their value for postsurgical outcome prediction when targeted during surgery, along with their stability over prolonged periods.

Methods

We analyzed iEEG data of 75 DRE children, including brief (5 min) data from patients with known Engel outcome (N = 59; used for outcome predi

SUBMITTER: Makaram N 

PROVIDER: S-EPMC12614818 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature