The relationship between cholesterol, high-density lipoprotein, and glucose index and hypertension: A study based on two national cohorts.

ABSTRACT: BackgroundHypertension remains a major global public health concern and is strongly linked to metabolic dysregulation. The cholesterol-high-density lipoprotein-glucose index, a recently proposed composite marker that integrates lipid and glycemic parameters, has not been comprehensively investigated in relation to hypertension.MethodsData from two nationally representative cohorts were analyzed: the China Health and Retirement Longitudinal Study (CHARLS) for longitudinal evaluation and the US National Health and Nutrition Examination Survey (NHANES) for cross-sectional assessment. Logistic regression analyses were used to examine the association between the cholesterol-high-density lipoprotein-glucose index and hypertension. Restricted cubic spline models were applied to assess potential n

SUBMITTER: Zhang Z 

PROVIDER: S-EPMC12614891 | biostudies-literature | 2025 Oct-Dec

REPOSITORIES: biostudies-literature