Prospective, randomized, controlled trial comparing PROpofol versus KetaMINE in rapid sequence intubation in critically ill patients (PROMINE): protocol paper and statistical analysis plan.

ABSTRACT:

Background

The optimal and safest hypnotic agent for rapid sequence intubation in critically ill patients remains uncertain. Factors such as hypovolemia, vasoplegia, hypoxemia, and acidosis can influence the efficacy and safety of induction agents. Propofol is commonly used for this purpose; however, it is associated with the risk of exacerbating hypotension. Ketamine, which has a more favorable hemodynamic profile, may offer a safer alternative in these patients.

Objective

To assess whether ketamine is a safer alternative to propofol for rapid sequence intubation by reducing the incidence of hypotension during induction in critically ill patients.

Methods

This will be a randomized, open-label, pragmatic, bicenter study. A total of 170 critically ill patients requirin

SUBMITTER: Schmidt RC 

PROVIDER: S-EPMC12614951 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature