Serosurveillance Identifies an Endemic Hotspot of Lassa Fever in Faranah, Upper Guinea.

ABSTRACT:

Background

Lassa fever, caused by Lassa virus (LASV), is a rodent-borne disease endemic to West Africa. Despite growing interest from the global health community, the overall disease burden remains poorly understood due to persistent underreporting and inadequate diagnostic capacities. This study aimed to assess LASV infection dynamics in rural Guinea, addressing gaps in understanding its epidemiology in endemic settings.

Methods

A cross-sectional serosurveillance study was conducted across 6 villages in Faranah, Guinea, involving 1306 participants. Serum samples were analyzed for LASV-specific antibodies using enzyme-linked immunosorbent assay, and a subset confirmed via immunofluorescence and neutralization assays. Statistical and mathematical models were used to estimate

SUBMITTER: Marien J 

PROVIDER: S-EPMC12614985 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature