Real-World Safety of Oral Isotretinoin in Patients During Sunny Months: Retrospective Cohort Study.

ABSTRACT:

Introduction

There is a widespread clinical practice of avoiding oral isotretinoin administration during the sunny season due to its purported photosensitizing effect. However, this approach is not supported by solid evidence.

Objective

The aim of this study was to assess the safety and effectiveness of administering oral isotretinoin at a reduced daily dosage during the sunny period in a real-world clinical setting.

Methods

This retrospective cohort study included all acne patients treated with oral isotretinoin at our Acne Clinic (January 2014 - December 2023) who had received the drug between June and September, when UV index exceeds a threshold of 6. Conventionally, oral isotretinoin daily dosage is reduced by approximately half during these four sunny months and

SUBMITTER: Marzola E 

PROVIDER: S-EPMC12615055 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature