GRWD1 Drives Melanoma Growth Through NF-κB Signaling Pathway.

ABSTRACT:

Introduction

Melanoma is an aggressive skin cancer with high metastatic potential. The oncogenic protein GRWD1 has been implicated in various cancer types, but its role in melanoma remains unclear.

Objectives

To examine the effects of GRWD1 knockdown on melanoma cell proliferation, apoptosis, and migration and to evaluate its prognostic significance in melanoma patients.

Methods

A combination of in vitro and clinical analyses was performed. A2058 melanoma cells were treated with GRWD1-specific siRNA, and cell proliferation, apoptosis, and migration assays were conducted. Western blotting was used to assess alterations in key oncogenic pathways. Additionally, clinical tissue samples from melanoma patients were analyzed for GRWD1 expression, and Kaplan-Meier survival an

SUBMITTER: Turkmen D 

PROVIDER: S-EPMC12615077 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature