Differential Expression of Claudin-3 and Claudin-1 in Mycosis Fungoides: Implications for Disease Monitoring.

ABSTRACT:

Introduction

Claudins are integral transmembrane proteins that play a pivotal role in regulating tight junctions within epithelial and endothelial cells. In addition to their fundamental function in preserving cell-cell adhesion and barrier integrity, claudins are implicated in various biological processes, including those critical to cancer development and dermatological disorders. However, the role of claudin-1 and claudin-3 in mycosis fungoides (MF) pathogenesis remains unexplored and has yet to be comprehensively studied.

Objectives

This study aimed to investigate the serum levels of claudin-1 and claudin-3 in MF patients and assess their potential clinical significance as biomarkers for disease progression.

Methods

A total of 88 MF patients and 88 healthy control

SUBMITTER: Aktas A 

PROVIDER: S-EPMC12615090 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature