Tretinoin for Photodamaged Facial Skin: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Introduction

Randomized controlled trials have suggested that tretinoin, a topical retinoid, can improve wrinkling in photodamaged skin; however, its overall effectiveness remains subject of debate.

Objectives

This study evaluated the efficacy and safety of tretinoin in treating facial wrinkles induced by photodamage.

Method

We systematically searched the PubMed, EMBASE, and Cochrane CENTRAL databases from their inception to 16 January 2024 to identify randomized controlled trials comparing topical tretinoin with vehicle treatments. Data were synthesized using a random effects model, and sensitivity analyses were performed to evaluate the robustness of the results in the presence of potential bias.

Results

This study identified eight trials (1,361 patients; med

SUBMITTER: Huang HY 

PROVIDER: S-EPMC12615114 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature