Nafamostat mesilate attenuates renal fibrosis by suppressing the IL-17 signaling pathway.

ABSTRACT:

Introduction

Chronic kidney disease (CKD) is a global public health concern characterized by progressive renal function decline and fibrosis, ultimately leading to end-stage renal disease (ESRD). Renal tubular injury and renal interstitial fibrosis are key contributor to this process. Granzyme B (GZMB), a serine protease, has been studied for its role in inducing apoptosis during immune defense. However, the role of GZMB in tubular injury and renal interstitial fibrosis remain unclear. Nafamostat mesylate (NM), a broad-spectrum serine protease inhibitor which is used for anticoagulation during hemodialysis in the clinic. This study aims to investigate the effects of GZMB on renal injury and renal interstitial fibrosis, and further explore the mechanisms of action NM intervention on

SUBMITTER: Liao W 

PROVIDER: S-EPMC12615172 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature