Motor system modulation by transcranial alternating current stimulation: insights from functional MRI-a scoping review.

ABSTRACT: Transcranial alternating current stimulation (tACS) is a non-invasive neuromodulation technique that delivers oscillatory currents to modulate endogenous brain rhythms. Frequency-specific effects on motor function have been reported, yet the neural mechanisms remain incompletely understood. This scoping review synthesizes functional MRI (fMRI) evidence on tACS-induced modulation of motor-related brain activity and connectivity in healthy individuals and patients with neurological conditions. A systematic search of the literature identified six eligible studies with a total of 108 participants, of whom 26 were individuals with chronic stroke. Stimulation frequencies ranged from 5 to 70 Hz, most often targeting the primary motor cortex. Gamma-band tACS (≥50 Hz) was generally associated with

SUBMITTER: Han S 

PROVIDER: S-EPMC12615180 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature