Genetic/epigenetic RNA dysregulation in type 2 <i>diabetes mellitus</i> complicated with ischemic heart disease.

ABSTRACT:

Introduction

Diabetes mellitus is a major independent determinant of cardiovascular morbidity. Therefore, we evaluated whether a molecular RNA panel comprising FZD5 and GTF2I could facilitate the early detection and discrimination of ischemic heart disease in individuals with type 2 diabetes mellitus.

Methods

We implemented a two-stage bioinformatics workflow to identify and validate two mRNA candidates associated with T2DM and IHD. Subsequently, we delineated non-coding RNAs linked to these transcripts and the pathways potentially implicated in T2DM complicated by IHD. Finally, we conducted a pilot case-control study and quantified the panel members by RT-qPCR in 56 patients with T2DM, 25 with IHD, 26 with combined T2DM+IHD, and 60 matched controls.

Results

SUBMITTER: Sedkey ES 

PROVIDER: S-EPMC12615181 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature