Modern antiseptics against multidrug-resistant <i>Pseudomonas aeruginosa</i>, emerging from war-related injuries in Ukraine.

ABSTRACT: Susceptibility testing of clinical multidrug-resistant (MDR) and reference P. aeruginosa strains was performed using the standard twofold serial dilution method. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of antiseptics were determined. MIC and MBC values were also interpreted as the bacteriostatic index of antiseptic activity (BSIAA) and the bactericidal index of antiseptic activity (BCIAA). The ability of strains to form biofilms, the inhibition of biofilm formation, and the destruction of mature biofilms under the influence of bacteriostatic, bactericidal, and ½ of the initial antiseptic concentration were modeled using Christensen's test. Antiseptics from the detergent group, decamethoxine (0.1 and 0.02%) and polyhexanide (0.1%), demo

SUBMITTER: Nazarchuk O 

PROVIDER: S-EPMC12615205 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature