Novel volumetric modulated arc therapy approach for lattice radiation therapy for bulky liver tumors.

ABSTRACT:

Purpose

Lattice radiation therapy (LRT) is a type of spatially fractionated radiation therapy that has emerged as an effective treatment approach for bulky solid tumors. RapidArc Dynamic (RAD) is a novel beam delivery approach that may be advantageous for LRT. The purpose of this in silico study was to evaluate and compare a novel RAD-based LRT approach (RAD-LRT) with conventional volumetric modulated arc therapy (VMAT)-based LRT (VMAT-LRT).

Methods

Twenty patients with bulky liver tumors treated with RT were retrospectively identified. VMAT-LRT and RAD-LRT plans were generated for all patients. Lattice spheres were placed in a standardized hexagonal pattern with alternating high-dose spheres (vertex tumor volume high [VTVH], analogous to the peak dose) and low-dose c

SUBMITTER: Chung CV 

PROVIDER: S-EPMC12615216 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature