Increased iron deposition in putamen and substantia nigra correlates with cognitive function in cerebral small vessel disease: A quantitative susceptibility mapping study.

ABSTRACT: Cerebral small vessel disease (CSVD) is a major contributor to stroke and dementia. Current neuroimaging markers inadequately explain its mechanisms. Sixty-one CSVD patients and 32 age- and sex-matched healthy controls (HC) were retrospectively analyzed. CSVD patients were divided into mild CSVD burden group and severe CSVD burden group according to the total CSVD burden score. The susceptibility values of deep nuclei were obtained based on quantitative susceptibility mapping. The differences in susceptibility values among the three groups were assessed using Kruskal-Wallis H test with Bonferroni correction, and correlations with MoCA-related cognitive scores were evaluated via Spearman's analysis. CSVD patients exhibited increased susceptibility values in bilateral caudate nucleus, putame

SUBMITTER: Feng M 

PROVIDER: S-EPMC12615235 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature