Site-Specific Biomarkers in Keloid Disease Differentiate Keloid Scars From Normal Skin, DFSP, and Fibrosarcoma: Insights From Cell and Tissue Analysis.

ABSTRACT: This preliminary study explores the feasibility of identifying novel site-specific biomarkers in keloid disease to enhance understanding of its pathobiology. Keloid scars are clinically and morphologically heterogeneous, showing variable response to therapy. They also differ at the cellular and molecular levels between their actively growing margins and their dormant centers. In addition, keloids behave differently to other fibrous skin tumors, including DSFP and FS. Thus, we performed a high-throughput RNA sequencing and gene/protein analysis on keloid tissue, primary keloid fibroblasts, and keloid-derived immortalized fibroblast cell lines from different sites of the keloid tissue (Extralesional, Peripheral, Middle, and Top). These were compared with normal skin, DFSP, and FS. We identif

SUBMITTER: Sadiq A 

PROVIDER: S-EPMC12615237 | biostudies-literature | 2026 Jan-Feb

REPOSITORIES: biostudies-literature