Eph-ephrin signaling affects lens growth and shape, nucleus size, and gradient refractive index in adult mice.

ABSTRACT:

Purpose

The function of the eye lens, to fine focus light from different distances onto the retina to form a clear image, relies on tissue biomechanical properties, refractive index, shape, and transparency. Increased lens stiffness with age, especially of the center or nucleus, has long been hypothesized to lead to presbyopia, a loss of accommodative ability, and the need for reading glasses. The cellular and molecular mechanisms that determine lens biomechanical properties and change during age-related stiffening remain unclear. Little is known about the factors that regulate lens shape and growth, nucleus size, and refractive index. We previously showed that loss of EphA2, a receptor tyrosine kinase, or ephrin-A5, a ligand for Eph receptors, leads to changes in lens shape and re

SUBMITTER: Flowers GM 

PROVIDER: S-EPMC12615243 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature