Outcomes of patients with suspected heparin-induced thrombocytopenia in a contemporary multicenter cohort.

ABSTRACT:

Abstract

Managing patients with suspected heparin-induced thrombocytopenia (HIT) poses significant clinical challenges. Limited evidence exists on how management decisions impact clinical outcomes, leading to treatment recommendations based on low-certainty evidence. This study aimed to evaluate the treatment strategies and clinical outcomes of patients with suspected HIT in a contemporary multicenter cohort. We conducted a prospective, multicenter cohort study including consecutive patients with suspected HIT from 11 centers. Patients were stratified into 3 groups: (1) HIT confirmed, (2) HIT-negative but heparin/platelet factor 4 (PF4) antibody-positive, and (3) HIT-negative without antibodies. Clinical and laboratory data were systematically collected. HIT was diagnosed using the

SUBMITTER: Nilius H 

PROVIDER: S-EPMC12615279 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature