Regional differences in APD restitution can initiate wavebreak and re-entry in cardiac tissue: a computational study.

ABSTRACT:

Background

Regional differences in action potential duration (APD) restitution in the heart favour arrhythmias, but the mechanism is not well understood.

Methods

We simulated a 150 x 150 mm 2D sheet of cardiac ventricular tissue using a simplified computational model. We investigated wavebreak and re-entry initiated by an S1S2S3 stimulus protocol in tissue sheets with two regions, each with different APD restitution. The two regions had a different APD at short diastolic interval (DI), but similar APD at long DI. Simulations were performed twice; once with both regions having steep (slope > 1), and once with both regions having flat (slope < 1) APD restitution.

Results

Wavebreak and re-entry were readily initiated using the S1S2S3 protocol in tissue sheets with two re

SUBMITTER: Clayton RH 

PROVIDER: S-EPMC1261529 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature