Network analysis of antimicrobial resistance in <i>Staphylococcus aureus</i>: characterization of hub genes and their functional implications.

ABSTRACT: Staphylococcus aureus is a pathogenic bacterium that is increasingly resistant to antibiotics. To identify genes that facilitate this resistance, we analyzed 1062 genomes from the NCBI Genome database. From these genomes, we compile a list of 229 antimicrobial resistance (AMR) genes from the CARD, ResFinder, MEGARes, and AR-ANNOT databases. We then constructed and analyzed their interaction network using multiple network analysis tools to identify critical central genes, designated as hub genes. Our findings revealed that mecA, fosB, arlR, mepA, mgrA, and arlS held the highest significance in the interaction network, suggesting their roles as key genes in AMR. To further examine these genes, we performed functional enrichment and molecular function analyses to better u

SUBMITTER: Hasan MI 

PROVIDER: S-EPMC12615354 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature