Engineered spermidine-secreting <i>Saccharomyces boulardii</i> enhances olfactory memory in <i>Drosophila melanogaster</i>.

ABSTRACT:

Introduction

The polyamines putrescine, spermidine, and spermine are ubiquitous metabolites synthesized in all cells. The intracellular levels of polyamines, especially spermidine, decrease in aging. Oral spermidine supplementation has been reported to alleviate aspects of aging-related disease in animal models, including decline in learning and memory. The diverse health benefits of spermidine supplementation, often at doses that do not significantly alter spermidine levels of target organs, suggests that exogenous spermidine may have a common site of action, the gastrointestinal (GI) tract.

Methods

To directly deliver spermidine to the GI tract with minimum impact on the global spermidine levels, we engineered the probiotic yeast Sacchromyces boulardii (Sb) t

SUBMITTER: Parweez F 

PROVIDER: S-EPMC12615376 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature