Brain connectivity moderated the effects of cognitive intraindividual variability on mobility in cognitively frail older adults.

ABSTRACT:

Introduction

Cognitive frailty, defined by the coexistence of mild cognitive impairment and physical frailty, imposes greater risk of negative health consequences than either condition alone. Cognitive intraindividual variability (IIV), which reflects the extent of fluctuation in cognitive performance, is an early indicator of impaired cognition and mobility. To extend current understanding of the underlying neural mechanisms of increased IIV due to cognitive frailty, this study investigated the association between brain networks, IIV, and mobility.

Methods

A total of 38 community-dwelling cognitively frail/non-cognitively frail older adults (CF and non-CF; n = 17 and n = 21, respectively) underwent clinical assessments including the Trail Making Test, Stroop T

SUBMITTER: Wu J 

PROVIDER: S-EPMC12615459 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature