Optimal fluid management strategies in patients with heart failure: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Fluid restriction is frequently recommended in heart failure (HF) management to prevent volume overload and improve clinical outcomes. However, the evidence supporting this practice remains limited. This meta-analysis aimed to evaluate the impact of fluid restriction vs. liberal fluid intake on clinical and patient-centered outcomes in individuals with HF.

Methods

A systematic search of PubMed, Embase, Cochrane Library, and ClinicalTrials.gov was conducted through April 27, 2025, to identify randomized controlled trials (RCTs) comparing restrictive and liberal fluid strategies in HF. Pooled risk ratios (RRs) for binary outcomes and weighted mean differences (WMDs) for continuous outcomes with 95% confidence intervals (CIs) were calculated using a random-effects mo

SUBMITTER: Adamu UG 

PROVIDER: S-EPMC12615477 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature