Lower reward sensitivity in frontostriatal stroke: Influence of depression and resting-state functional connectivity.

ABSTRACT: Stroke patients have shown low reward sensitivity, which is a transdiagnostic dimension that defines the extent to which a person actively pursues rewarding stimuli. Low reward sensitivity has been related to depression and dysregulation of the frontostriatal network. To date, studies have addressed this dimension in heterogenic stroke lesions and the underlying mechanisms of frontostriatal stroke patients are still unknown. This study included 54 participants (32 chronic frontostriatal stroke patients and 22 healthy controls). Reward sensitivity was assessed using the probabilistic reversal learning task. Depressive symptoms were measured with the Adult Self-Report, and resting-state functional connectivity (rsFC) was examined using functional near-infrared spectroscopy (fNIRS) in prefron

SUBMITTER: Sanchez-Kuhn A 

PROVIDER: S-EPMC12615514 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature