Management of Erythrodermic Psoriasis with Systemic Therapies: A Systematic Review.

ABSTRACT:

Background

Erythrodermic psoriasis (EP) is a severe and rare variant of psoriasis. Clinical features include scaling and erythema affecting more than 75% of body surface area, associated with systemic symptoms such as lymphadenopathy, arthralgia, fever, fatigue, dehydration, serum electrolyte disturbances, and tachycardia, making this condition a potentially life-threatening disease. Differential diagnosis can be challenging, encompasses atopic dermatitis, cutaneous adverse drug reaction, and advanced cutaneous lymphoma. Following a correct diagnostic framing, appropriate systemic treatment must be initiated. Unfortunately, there are no recent up-to-date guidelines and standardized treatment options for EP are still lacking.

Objective

To review the current reported systemic

SUBMITTER: Mastorino L 

PROVIDER: S-EPMC12615535 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature