Outcomes of venovenous-extracorporeal membrane oxygenation bridging in lung transplant recipients with panel reactive antibody positivity.

ABSTRACT:

Background

Lung transplantation improves survival in advanced lung disease, but calculated Panel Reactive Antibody (cPRA) positive patients are at higher risk for adverse outcomes. It is unclear if sensitization poses additional risks in patients bridged to transplantation with venovenous extracorporeal membrane oxygenation (VV-ECMO). This study compares outcomes between cPRA-positive and -negative patients bridged with VV-ECMO.

Methods

Among 411 transplant recipients from an institutional lung transplantation database (January 2018-March 2025), 52 patients were bridged with VV-ECMO. Of these, 14 were cPRA-positive and 38 were cPRA-negative. Univariate and multivariate analyses evaluated early post-transplant complications and survival outcomes in cPRA-positive and -negative

SUBMITTER: Chang A 

PROVIDER: S-EPMC12615553 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature