Intraoperative hypotension after remimazolam or propofol induction with sevoflurane maintenance in angiotensin II receptor blockers-treated patients: a randomized controlled trial.

ABSTRACT: Robot-assisted laparoscopic prostatectomy (RALP) is associated with hemodynamic shifts; patients on angiotensin receptor blockers (ARBs) are especially susceptible to intraoperative hypotension. We investigated whether induction with remimazolam reduces the intraoperative hypotension incidence and severity compared with propofol in this population. Herein, 112 hypertensive patients undergoing RALP who continued ARB therapy received remimazolam (0.2 mg/kg) or propofol (1-1.5 mg/kg) for anesthetic induction. The primary endpoint was hypotension occurrence (mean arterial pressure [MAP] < 65 mmHg sustained for ≥ 1 min), assessed during the entire anesthesia and 15 min post-induction. Secondary endpoints included MAP < 55 mmHg sustained for ≥ 1 min, time-weighted average (TWA)-MAP < 65 mmHg or

SUBMITTER: Kim HJ 

PROVIDER: S-EPMC12615582 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature